Manchester United welcome Liverpool to Old Trafford in one of the biggest fixtures of the Premier League season so far.
The outcome of the tie could have massive implications in both the race for the title and the top four, as Carabao Cup finalists Chelsea and Manchester City eagerly await the result ahead of their Wembley clash later.
But the Red Devils will have to make do without several key players, with Anthony Martial and Nemanja Matic both missing from the matchday squad, as Scott McTominay starts in the centre of midfield.
Jesse Lingard is only fit enough for a place on the bench, while Alexis Sanchez drops out of the starting XI after the FA Cup victory over Chelsea on Monday night.
Romelu Lukaku retains his place in the team and starts in a centre-forward role, with Marcus Rashford deployed out wide for the second game running.
Antonio Valencia, Matteo Darmian and Marcos Rojo are all still fighting their way back from injury.
You can listen to the action unfold live on talkSPORT, with kick-off at 2.05pm.
Confirmed Man United XI to face Liverpool
Man United: de Gea, Young, Smalling, Lindelof, Shaw, Ander Herrera, McTominay, Pogba, Mata, Lukaku, Rashford.
Subs: Bailly, Sanchez, Lingard, Andreas Pereira, Fred, Dalot, Romero.