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Liverpool were dealt a huge injury blow with Roberto Firmino leaving Old Trafford on crutches following their stalemate at the home of their arch rivals Manchester United on Sunday.
The Brazilian striker rolled his ankle and was subsequently replaced by Daniel Sturridge after just half an hour played.
Bizarrely, a combined FOUR SUBSTITUTIONS were made in the first-half with players dropping like flies.
It was first time since February 2009 that four substitutions occurred in the first half of a top-flight game.
Manchester United were forced to use all three of their substitutions when Ander Herrera, Juan Mata and Jesse Lingard all went down injured.
Lingard, who was a doubt for the fixture, had been introduced for Mata when he was forced off just 20 minutes later.
The hosts entered the game without Anthony Martial and Nemanja Matic, and their injury crisis continues to grow worse by the minute.
Meanwhile, fans on Twitter were left bemused by the crazy number of injuries inside the first half.
Here are the best Tweets: